The likely development of healthcare alliances and affiliations will c
reate a logical role for multicentered DUEs that study treatment regim
ens or indications in a healthcare system made up of several instituti
ons. Such a study is under way in New Jersey, involving 15 hospitals.
The DUE is evaluating usage patterns of ticarcillin/clavulanate and tw
o other broad-spectrum antibiotics. A multicenter DUE presents challen
ges, such as the need for additional resources and for consensus among
disparate elements; but this methodology also opens up expanded roles
for pharmacists, including participation in quality assurance activit
ies.