ON THE PATHOGENESIS OF IDDM

Authors
NERUP J MANDRUPPOULSEN T HELQVIST S ANDERSEN HU POCIOT F REIMERS JI CUARTERO BG KARLSEN AE BIERRE U LORENZEN T
Citation
J. Nerup et al., ON THE PATHOGENESIS OF IDDM, Diabetologia, 37, 1994, pp. 190000082-190000089
Citations number
63
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
Journal title
Diabetologia → ACNP
ISSN journal
0012186X
Volume
37
Year of publication
1994
Supplement
2
Pages
190000082 - 190000089
Database
ISI
SICI code
0012-186X(1994)37:<190000082:OTPOI>2.0.ZU;2-H
Abstract
A model of the pathogenesis of insulin-dependent diabetes mellitus, i. e. the initial phase of beta-cell destruction, is proposed: in a casca de-like fashion efficient antigen presentation, unbalanced cytokine, s ecretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O-2(-) and nitric oxide) produced by the beta ce lls themselves. This entire process is under polygenetic control.