TOTAL SYNTHESIS OF (-)-BALANOL

Authors
LAMPE JW HUGHES PF BIGGERS CK SMITH SH HU H
Citation
Jw. Lampe et al., TOTAL SYNTHESIS OF (-)-BALANOL, Journal of organic chemistry, 59(18), 1994, pp. 5147-5148
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
18
Year of publication
1994
Pages
5147 - 5148
Database
ISI
SICI code
0022-3263(1994)59:18<5147:TSO(>2.0.ZU;2-F
Abstract
(-)-Balanol, a fungal metabolite with potent protein kinase C inhibito ry properties, has been prepared in a total synthesis which makes use of an anionic homo-Fries rearrangement approach to the benzophenone su bunit and in which the azepane subunit is obtained from (2S,3R)-3-hydr oxylysine.