Cases of onychomycosis represent up to 30% of diagnosed superficial fu
ngal infections and are caused by three groups of fungi: dermatophytes
, yeasts, and nondermatophytic molds. The majority of toenail infectio
ns are caused by dermatophytes; Trichophyton rubrum is isolated with t
he greatest frequency. In infections of fingernails, Candida species c
an be isolated as frequently as the dermatophytes. Of the molds, Scyta
lidium species can infect both fingernails and toenails, as well as ad
jacent skin, and represent 3% of the nail infections in a temperate co
untry such as the United Kingdom but a much higher proportion in tropi
cal countries. Other molds such as Scopulariopsis, Acremonium, and Asp
ergillus species can infect damaged nails. The isolation of a dermatop
hyte is always considered indicative of infection, but the presence of
other molds, which may be aerial contaminants, must be interpreted wi
th care.