ANTIFUNGAL THERAPY - POTENTIAL INTERACTIONS WITH OTHER CLASSES OF DRUGS

Combination drug therapy is widely used for the management of many com mon medical conditions. The concurrent use of more than one drug can s ignificantly alter the therapeutic and side-effect profile of each ind ividual agent. Such drug-drug interactions are generally classified ei ther as pharmacokinetic or pharmacodynamic. Oral agents used for the m anagement of superficial fungal infections can have both types of inte ractions. This article describes common drug-drug interactions observe d with amphotericin B, flucytosine, griseofulvin, ketoconazole, flucon azole, and itraconazole.