To clarify the effects of a thermal environment on rats, histopatholog
ical changes, and temperatures in the rectum and eyes of Fischer strai
n rats exposed to a thermal environment of 32-degrees-C for 2 days or
7 days were investigated. Thermal exposure to 32-degrees-C induced ele
vations in rectal and ocular temperatures. The increased temperature l
evels persisted during the thermal exposure. Vacuolar degeneration sur
rounding the hepatic vein was observed in rat livers exposed to 32-deg
rees-C for 7 days. No abnormalities were observed in other organs. The
se results indicate that thermal exposure to 32-degrees-C induces vacu
olar degeneration in hepatocytes due to the elevation of body temperat
ure.