BLOOD BIOCHEMICAL AND URINARY CHANGES IN OXYTETRACYCLINE INDUCED NEPHROTOXICITY IN GOATS

Nephrotoxicity was induced in goats by 3 intramuscular injections of l ong-acting oxytetracycline on alternate days (@ 50 mg/kg b wt. The ser um values of urea nitrogen, creatinine and uric acid were markedly ele vated along with significant rise in potassium. total protein and alka line phosphatase, and decrease in calcium and inorganic phosphorus and normal sodium concentration. Urinalysis revealed significant decline of specific gravity and pH along with moderate presence of protein and granular/epithelial casts. Markedly low urea nitrogen and creatinine and increased inorganic phosphorus and phosphate activity in the urine were observed.