The first measurement of two-nucleon pion absorption in He-4 at 1 GeV/
c has been performed at the KEK 12 GeV proton synchrotron. Both the (p
i+, pp) and (pi+, pn) modes were measured and clearly identified, even
at this energy. An isospin dependence was obtained which was differen
t from that in the DELTA-energy region.