DECREASED CEREBROSPINAL-FLUID LEVELS OF BETA-ENDORPHIN IN JAPANESE PATIENTS WITH JOSEPH DISEASE

Authors
MATSUISHI T SAKAI T NAGAMITSU S KOMORI H IWASHITA H KATO H
Citation
T. Matsuishi et al., DECREASED CEREBROSPINAL-FLUID LEVELS OF BETA-ENDORPHIN IN JAPANESE PATIENTS WITH JOSEPH DISEASE, Annals of neurology, 36(3), 1994, pp. 441-443
Citations number
15
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
36
Issue
3
Year of publication
1994
Pages
441 - 443
Database
ISI
SICI code
0364-5134(1994)36:3<441:DCLOBI>2.0.ZU;2-E
Abstract
We measured the cerebrospinal fluid (CSF) levels of beta-endorphin in 7 Japanese patients with Joseph disease and compared them with control values. The 7 patients included 4 with type I and 3 with type II dise ase; their mean age was 45.7 +/- 12.09 years. Diseased controls were m atched in age to the patients studied. In these patients, CSF beta-end orphin level was significantly lower than in the controls (40% of norm al values). An alteration in CSF beta-endorphin level may explain some of the neurological impairment found in Joseph disease.