SYNTHESIS OF MEBMT C9 AMINO-ACID PRESENT IN CYCLOSPORINE, AND ANALOGS

Authors
DURAND JO GENET JP
Citation
Jo. Durand et Jp. Genet, SYNTHESIS OF MEBMT C9 AMINO-ACID PRESENT IN CYCLOSPORINE, AND ANALOGS, Bulletin de la Societe chimique de France, 131(6), 1994, pp. 612-619
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology,Chemistry
Journal title
Bulletin de la Societe chimique de France → ACNP
ISSN journal
00378968
Volume
131
Issue
6
Year of publication
1994
Pages
612 - 619
Database
ISI
SICI code
0037-8968(1994)131:6<612:SOMCAP>2.0.ZU;2-5
Abstract
The asymmetric syntheses of (4R)-4-((E)but-2-enyl)-4,N-dimethyl-L-thre onine, MeBmt, are reviewed and discussed. This unusual amino acid is e ssential for the biological activity of cyclosporine (CsA) which is us ed clinically to suppress the rejection of transplanted human organs.