ACYLATION OF DIETHYL ACETAMIDOMALONATE - SYNTHESIS AND REACTIVITY OF 4-ETHOXYCARBONYLOXAZOLE

Authors
LOUPY A PETIT A ZAPARUCHA A MAHIEU C SEMERIA D
Citation
A. Loupy et al., ACYLATION OF DIETHYL ACETAMIDOMALONATE - SYNTHESIS AND REACTIVITY OF 4-ETHOXYCARBONYLOXAZOLE, Bulletin de la Societe chimique de France, 131(6), 1994, pp. 642-647
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology,Chemistry
Journal title
Bulletin de la Societe chimique de France → ACNP
ISSN journal
00378968
Volume
131
Issue
6
Year of publication
1994
Pages
642 - 647
Database
ISI
SICI code
0037-8968(1994)131:6<642:AODA-S>2.0.ZU;2-V
Abstract
The acylation of diethyl acetamidomalonate by palmitoyl chloride was p erformed using KOtBu in THF. Subsequent reaction of acylmalonate with DMSO or NMP led to ethyl 5-alkyloxazole-4-carboxylate (global yield 76 % for the two steps). Some original reactions of this heterocycle are presented, including ring opening of oxazole.