A. Loupy et al., ACYLATION OF DIETHYL ACETAMIDOMALONATE - SYNTHESIS AND REACTIVITY OF 4-ETHOXYCARBONYLOXAZOLE, Bulletin de la Societe chimique de France, 131(6), 1994, pp. 642-647
The acylation of diethyl acetamidomalonate by palmitoyl chloride was p
erformed using KOtBu in THF. Subsequent reaction of acylmalonate with
DMSO or NMP led to ethyl 5-alkyloxazole-4-carboxylate (global yield 76
% for the two steps). Some original reactions of this heterocycle are
presented, including ring opening of oxazole.