Science policy issues have recently joined technology issues in being
acknowledged to have strategic importance for national 'competitivenes
s' and 'economic security'. The economics literature addressed specifi
cally to science and its interdependences with technological progress
has been quite narrowly focused, and has lacked an overarching concept
ual framework to guide empirical studies and public policy discussions
in this area. The emerging 'new economics of science', described by t
his paper, offers a way to remedy these deficiencies. It makes use of
insights from the theory of games of incomplete information to synthes
ize the classic approach of Arrow and Nelson in examining the implicat
ions of the characteristics of information for allocative efficiency i
n research activities, on the one hand, with the functionalist analysi
s of institutional structures, reward systems and behavioral norms of
'open science' communities-associated with the sociology of science in
the tradition of Merton-on the other. An analysis is presented of the
gross features of the institutions and norms distinguishing open scie
nce from other modes of organizing scientific research, which shows th
at the collegiate reputation-based reward system functions rather well
in satisfying the requirement of social efficiency in increasing the
stock of reliable knowledge. At a more fine-grain level of examination
, however, the detailed workings of the system based on the pursuit of
priority are found to cause numerous inefficiencies in the allocation
of basic and applied science resources, both within given fields and
programs and across time. Another major conclusion, arrived at in the
context of examining policy measures and institutional reforms propose
d to promote knowledge transfers between university-based open science
and commercial R&D, is that there are no economic forces that operate
automatically to maintain dynamic efficiency in the interactions of t
hese two (organizational) spheres. Ill-considered institutional experi
ments, which destroy their distinctive features if undertaken on a suf
ficient scale, may turn out to be very costly in terms of long-term ec
onomic performance.