M. Nakamura et al., IGA NEPHROPATHY ASSOCIATED WITH PORTAL-HYPERTENSION IN LIVER-CIRRHOSIS DUE TO NONALCOHOLIC AND NON-A, NON-B, NON-C HEPATITIS, Internal medicine, 33(8), 1994, pp. 488-491
A 69-year-old female was admitted to our hospital because of leg edema
, proteinuria (2.1 g/day), and gross hematuria. She had non-alcoholic
liver cirrhosis of unknown etiology. Esophageal varices also were foun
d. Examination of the renal biopsy specimen revealed mesangial prolife
rative glomerulonephritis with IgA deposits. Propranolol was administe
red orally to reduce portal hypertension, resulting in a progressive d
ecrease in urinary microalbumin excretion. This case suggests that por
tal hypertension is involved in the pathogenesis of IgA nephropathy in
liver cirrhosis.