EVALUATION OF 2 GONADOTROPIN-RELEASING-HORMONE (GNRH) ANALOGS (LEUPROLIDE AND BUSERELIN) IN SHORT AND LONG PROTOCOLS FOR ASSISTED REPRODUCTION TECHNIQUES
Bc. Tarlatzis et al., EVALUATION OF 2 GONADOTROPIN-RELEASING-HORMONE (GNRH) ANALOGS (LEUPROLIDE AND BUSERELIN) IN SHORT AND LONG PROTOCOLS FOR ASSISTED REPRODUCTION TECHNIQUES, Journal of assisted reproduction and genetics, 11(2), 1994, pp. 85-91
Purpose: The administration of two GnRH analogues (buserelin and leupr
olide acetate) in long and short protocols was evaluated prospectively
. In the long protocol, the analogues were given from day 1 of the cyc
le for at least 14 days and then hMG administration was started, while
in the short protocol the analogues were initiated from cycle day 1,
adding hMG from day 3. The patients were divided into four groups acco
rding to the protocol used: Group I, buserelin-long; Group II, buserel
in-short; Group III, leuprolide-long; and Group IV, leuprolide-short.
Serum E2 levels on the day of hCG injection and the number of follicle
s observed, oocytes retrieved, and embryos obtained, as well as implan
tation rates, were significantly higher (P < 0.001) in the long protoc
ols than in the short ones. Results: Pregnancy rates were similar in a
ll groups, although a trend for better results was observed in buserel
in-long compared to buserelin-short. There were no differences in the
results achieved with buserelin or leuprolide. Conclusion: The adminis
tration of GnRH analogues (buserelin and leuprolide acetate) in long p
rotocols induced a more intense ovarian response and was associated wi
th significantly higher implantation rates and also a trend for higher
pregnancy rates, although this difference was not statistically signi
ficant.