A patient with a cervical spinal cord injury receiving intrathecal bac
lofen for spasticity control underwent a 7 week course of hyperbaric o
xygen therapy to induce healing of an ischial decubitus ulcer. After c
ompletion of this treatment and during a routine baclofen infusion pum
p refill, the actual pump reservoir volume exceeded computer measureme
nts obtained with telemetry. Examination of the physiology of hyperbar
ic oxygen therapy in relation to infusion pump function revealed that
the intraspinal pressures attained during hyperbaric oxygen therapy pr
oduced retrograde leakage of cerebrospinal fluid into the infusion pum
p reservoir.