The natriuretic effects of furosemide and the long-acting loop diureti
c torasemide have been compared in patients with chronic renal failure
with and without nephrotic syndrome. In patients with chronic renal f
ailure without nephrotic syndrome, furosemide and torasemide exerted s
imilar natriuretic activity. In patients with chronic renal failure co
mplicated by nephrotic syndrome, torasemide showed a greater natriuret
ic potency and a longer duration of action than furosemide.