SEVERE EPISODE OF HIGH FEVER WITH RASH, LYMPHADENOPATHY, NEUTROPENIA,AND EOSINOPHILIA AFTER MINOCYCLINE THERAPY FOR ACNE

Minocycline is a tetracycline agent frequently used for acne therapy. It has a few rare but severe side effects that are not widely known bu t should be recognized early as drug related. These include acute hepa titis and liver failure; a Loffloer- like syndrome with pulmonary infi ltrates, wheezing, fever, and eosinophilia; skin eruptions, eosinophil ic cellulitis, and pustular folliculitis with eosinophilia; and a lupu slike syndrome. Side effects that are better known and recognized incl ude photosensitization, skin exanthema with pruritus, and pseudotumor cerebri.