Pv. Kuzmich et al., RHEUMATIC MANIFESTATIONS IN PATIENTS WITH MYELODYSPLASTIC AND MYELOPROLIFERATIVE DISEASES, Journal of rheumatology, 21(9), 1994, pp. 1649-1654
Objective. To evaluate the rheumatic complications in patients with my
elodysplastic and myeloproliferative diseases. Methods. A retrospectiv
e chart review of patients with a rheumatic disease and either a myelo
dysplastic or myeloproliferative disorder diagnosed on bone marrow exa
mination. Results. Nine patients were identified, 5 with myelodysplast
ic and 4 with myeloproliferative disorders. Polyarthritis was the most
common rheumatic presentation, occurring in 6 patients with a positiv
e rheumatoid factor in 4. Necrotizing vasculitis complicated the cours
e in 3 patients. Autoantibodies and hypergammaglobulinemia were presen
t in the majority of patients. Conclusion. There is an association bet
ween hematologic disorders caused by proliferation of bone marrow deri
ved pluripotent stem cells and rheumatic disorders.