De. Banet et al., ORAL METRONIDAZOLE, AN EFFECTIVE TREATMENT FOR SWEETS-SYNDROME IN A PATIENT WITH ASSOCIATED INFLAMMATORY BOWEL-DISEASE, Journal of rheumatology, 21(9), 1994, pp. 1766-1768
A 39-year-old woman with chronic, recurrent Sweet's syndrome (acute fe
brile neutrophilic dermatosis) and possible Crohn's disease was succes
sfully treated with oral metronidazole. After 4 years of recurrent ski
n lesions which involved the hands and face, our patient developed gen
ital and perianal ulcerations which were also histopathologically char
acterized by a neutrophilic infiltrate. In addition, she had a nondefo
rming polyarthritis that accompanied recurrences of her skin lesions.
The patient was given oral metronidazole, an agent frequently used for
perianal Crohn's disease, and achieved complete resolution of the per
ianal and perineal ulcers, the cutaneous lesions of Sweet's syndrome a
nd the associated polyarthritis.