DISSOLUTION KINETICS OF GRISEOFULVIN IN MIXED MICELLAR SOLUTIONS

The dissolution kinetics of the poorly water soluble, lipophilic model drug substance griseofulvin were studied in solutions containing simp le and mixed micelles of sodium cholate (BS) and phosphatidylcholine ( PC). Variables under investigation were the concentration of BS and th e ratio PC/BS. A rotating disk apparatus was used to monitor the disso lution process. With this method, (mixed) micellar diffusion coefficie nts could be calculated and some detailed information about the physic ochemical behavior and composition of mixed PC/BS micelles could be de rived.