M. Takei et al., EFFECT OF CONTIGNASTEROL ON HISTAMINE-RELEASE INDUCED BY ANTIIMMUNOGLOBULIN-E FROM RAT PERITONEAL MAST-CELLS, Journal of pharmaceutical sciences, 83(9), 1994, pp. 1234-1235
In rat peritoneal mass cells induced by anti-immunoglobulin E (anti-Ig
E), contignasterol (1) inhibited histamine release in a dose-dependent
manner. On the other hand, a reduction product of contignasterol (2)
did not inhibit histamine release from mast cells induced by anti-IgE.