CRYSTAL AND MOLECULAR-STRUCTURES OF TRICYCLIC NEUROLEPTICS

The X-ray crystal structures of three tricyclic neuroleptics have been completed and are reported herein. These include amitriptyline hydroc hloride (I), chlorprothixene hydrochloride (II), and ethopropazine hyd rochloride (III). The structures were compared with the structures of similar molecules with similar pharmacological activity. It was found that there is a great deal of flexibility in the structures of these m olecules, which makes it difficult to determine the pharmacologically active conformations. Crystallographic data: (I) C20H24NCl, monoclinic space group P2(1)/a, a = 13.812(4) Angstrom, b = 9.140(2) Angstrom, c = 14.345(4) Angstrom, beta = 96.82(2)degrees, Z = 4, final R = 0.059 for 1630 observed (I > 3 sigma(I)) reflections. (II) C18H20NSCl2.CHCl3 , monoclinic space group C2/c, a = 29.416(4) Angstrom, b = 6.986(1) An gstrom, c = 23.374(3) Angstrom, beta = 109.78(1)degrees, Z = 8, final R = 0.046 for 1436 observed reflections. (III) C19H25N2SCl, monoclinic space group P2(1)/c, a = 8.849(1) Angstrom, b = 14.475(2) Angstrom, c = 14.832(1) Angstrom, beta = 98.72(1)degrees, Z = 4, final R = 0.039 for 2583 observed reflections.