STUDY OF LOCAL-ANESTHETICS .123. HPLC STUDY OF PENTACAINE, HEPTACAINEAND CARBISOCAINE

Authors
BEDNARIKOVA A LEHOTAY J CIZMARIK J
Citation
A. Bednarikova et al., STUDY OF LOCAL-ANESTHETICS .123. HPLC STUDY OF PENTACAINE, HEPTACAINEAND CARBISOCAINE, Die Pharmazie, 49(8), 1994, pp. 577-579
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
8
Year of publication
1994
Pages
577 - 579
Database
ISI
SICI code
0031-7144(1994)49:8<577:SOL.HS>2.0.ZU;2-O
Abstract
A relationship between the capacity factor k' of pentacaine, heptacain e and carbisocaine and mobile phase composition (content of methanol a nd water, ionic strength and pH) has been studied by HPLC. It has been found that there is a linear relationship between log k' and the cont ent of methanol in the mobile phase in the range 80-100% (vol) of meth anol. The ionic strength of solute also has an influence on log k'. Wh en the amount of solute is higher than 0.25 mol/l, than its influence on log k' is not important. The pH = pK inflection point of sigmoidal dependence k' = f(pH) can be found.