COMBINED FACTOR AND QSAR ANALYSIS FOR ANTIBACTERIAL AND PHARMACOKINETIC DATA FROM PARALLEL BIOLOGICAL MEASUREMENTS

Antibacterial potency data for a variety of bacterial strains and phar macokinetic parameters of naphthyridines taken from the literature wer e submitted to factor and QSAR analyses. Factor analysis of antibacter ial potencies unraveld a distinct data structure. The information obta ined about the internal relatedness of tests can be used in QSAR analy ses and reflects itself in the QSAR results. Factor analysis of pharma cokinetic data also led to a clear grouping of measurements with a str ong relationship of half life time and urinary recovery, respectively, with log D.