6-ALLYL-5,6-DIHYDRO-5-HYDROXYPYRAN-2-ONE, A LACTONE PRODUCED BY A NEWDRECHSLERA SPECIES - SPECIFIED H-1 AND C-13 NMR ASSIGNMENTS, MUTAGENIC AND IMMUNOMODULATING TESTINGS

Authors
KRIVOBOK S THOMASSON F SEIGLEMURANDI F STEIMAN R BOTTEXGAUTHIER C
Citation
S. Krivobok et al., 6-ALLYL-5,6-DIHYDRO-5-HYDROXYPYRAN-2-ONE, A LACTONE PRODUCED BY A NEWDRECHSLERA SPECIES - SPECIFIED H-1 AND C-13 NMR ASSIGNMENTS, MUTAGENIC AND IMMUNOMODULATING TESTINGS, Die Pharmazie, 49(8), 1994, pp. 605-607
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
8
Year of publication
1994
Pages
605 - 607
Database
ISI
SICI code
0031-7144(1994)49:8<605:6ALPBA>2.0.ZU;2-I
Abstract
A lactone (6-allyl-5,6-dihydro-5-hydroxypyran-2-one) was isolated from a new Drechslera sp. H-1 and C-13 NMR assignments, not previously spe cified, are published. No mutagenic activity on Ames/Salmonella test ( strains TA98 and TA100 has been observed. Results on the respiratory m etabolism of J774.1 murine macrophage indicate that the lactone might exhibit immuno-modulating activity as a function of time of cellular c ontact and of concentration.