HERPES-SIMPLEX CHRONIC LARYNGITIS AND VOCAL CORD LESIONS IN A PATIENTWITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME

Chronic laryngitis in patients with acquired immunodeficiency syndrome may be due to infections or tumors, such as Kaposi's sarcoma and non- Hodgkin's lymphoma. We present what we believe to be the first proven case of herpes simplex virus chronic laryngitis in a man positive for human immunodeficiency virus. Direct laryngoscopy showed leukoplakic l esions on both vocal cords. Biopsy of the lesions showed squamous epit helial cells with the characteristic features of herpes simplex virus, which was confirmed by immunohistochemical stains. We discuss the dif ferential diagnosis of chronic laryngitis in a human immunodeficiency virus infection. Herpes simplex viral infection of the vocal cords sho uld be considered in patients with acquired immunodeficiency syndrome presenting with chronic hoarseness and leukoplakic lesions on direct l aryngoscopy, especially with no evidence of Kaposi's sarcoma, tumor, o r cytomegaloviral or fungal infection elsewhere. Treatment should be a cyclovir, except in the face of acyclovir resistance.