EVALUATION OF LUDIPRESS AS A MULTIPURPOSE-EXCIPIENT FOR DIRECT COMPRESSION .2. INTERACTIVE BLENDING AND TABLETING WITH MICRONIZED GLIBENCLAMIDE

In the second part of this publication the differing interactions of m icronized glibenclamide during mixing with four filler/binders for dir ect compression were studied. The excipients used were: Ludipress, Cel lactose, Avicel PH 200 and Karion Instant. In order to prepare interac tive mixtures, increasing amounts of micronized glibenclamide were ble nded with filler/binder fractions of 125 to 500 mu m. The degree of in teractivity was determined by air jet sifting of the mixes, comparing drug content in the mixes before and after sieving. Cellactose showed the highest adhesion tendency for glibenclamide due to the large cavit ies in the particles, leading to a reagglomeration within these caviti es. Tablets containing 1.75, 3.50, 5.00 and 10.00 mg of glibenclamide per tablet were compressed with Cellactose and Ludipress. As previousl y reported (1) for Cellactose based placebo tablets, Cellactose also s howed a tremendous increase in disintegration time and a prolonged dis solution rate at compaction pressures above 100 MPa. The corresponding values of Ludipress were not influenced. Therefore in terms of a mult ipurpose-excipient, Ludipress should be given preference in the formul ation of low dosed drugs.