The desalination process industries have largely tried to solve contro
l problems by conventional rather than modern control techniques that
are attracting widespread industrial applications and revolutionizing
process control as a result of advances in control theory. Control sys
tems are designed from mathematical models that are generally imperfec
t descriptions of real processes. It is widely accepted that conventio
nal PID or PI controllers may not provide satisfactory performance in
view of nonlinearity and uncertainty in the real world of desalination
processes. It is essential that control systems operate satisfactoril
y over a wide range of process conditions. The practice of multi stage
flash (MSF) desalination process control, process design, optimizatio
n, conspicuously lags behind contemporary theoretical developments. Co
nventional process control techniques do not ensure the safest and the
most profitable operation of processes when compared with advanced pr
ocess control which uses the knowledge of process economics and provid
es insight into the process to maintain essential variables at optimum
setpoints. This paper is an attempt to promote excellence and innovat
ion in desalination engineering and to remove barriers to advanced pro
cess control. Attempted here is brief clarification of some aspects of
advanced control strategies in terms of answers to the questions: Adv
ance control strategies: What are they? Where and when are they applic
able? and What can be expected of them? Although the reference here is
to MSF plants, some of the observations and remarks are also relevant
to process control practice in general. In the end, the conclusions p
oint out the complexity of the real world control problem which behove
s us to advocate the application of techniques such as self-optimizing
control strategies and artificial intelligence (AI) leading to an int
egrated system of intelligent control.