COMPARISON OF PESTIVIRUS MULTIPLICATION IN CELLS OF DIFFERENT SPECIES

Twenty-four pestiviruses, comprising 11 from pigs, eight from cattle a nd five from sheep, were tested for their ability to replicate in cell s of porcine, bovine and ovine origin. Seven of the viruses were succe ssfully passaged in all three cell types. Four porcine isolates (hog c holera virus) replicated to significant titres only in porcine cells. One bovine virus grew well in bovine cells but only poorly in ovine ce lls and not at all in porcine cells. The remaining 12 viruses could re plicate in cells from two of the three host species. The pattern of re plication in different cell types varied between different isolates of the same virus species.