OXA-PROSTANOID ANALOGS - IDENTIFICATION OF AN ORALLY EFFECTIVE, DUAL THROMBOXANE RECEPTOR ANTAGONIST THROMBOXANE SYNTHASE INHIBITOR

Authors
VLATTAS I DELLUREFICIO J COHEN DS LEE W CLARKE F DOTSON R MATHIS J ZOGANAS H
Citation
I. Vlattas et al., OXA-PROSTANOID ANALOGS - IDENTIFICATION OF AN ORALLY EFFECTIVE, DUAL THROMBOXANE RECEPTOR ANTAGONIST THROMBOXANE SYNTHASE INHIBITOR, Bioorganic & medicinal chemistry letters, 4(17), 1994, pp. 2073-2076
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
17
Year of publication
1994
Pages
2073 - 2076
Database
ISI
SICI code
0960-894X(1994)4:17<2073:OA-IOA>2.0.ZU;2-A
Abstract
The synthesis and pharmacological evaluation of oxa-prostanoid analogs with dual thromboxane receptor antagonist (TxRA)/thromboxane synthase inhibitor (TxSI) activities are described. One analog 6 with the desi rable long lasting oral TxRA/TxSI activity has been identified