STRUCTURAL ANALOGS OF LY292728, A HIGHLY POTENT XANTHONE DICARBOXYLIC-ACID LEUKOTRIENE B-4 RECEPTOR ANTAGONIST - SPATIAL POSITIONING OF THESECONDARY ACID GROUP

Authors
SAWYER JS SCHMITTLING EA BACH NJ BAKER SR FROELICH LL SAUSSY DL MARDER P JACKSON WT
Citation
Js. Sawyer et al., STRUCTURAL ANALOGS OF LY292728, A HIGHLY POTENT XANTHONE DICARBOXYLIC-ACID LEUKOTRIENE B-4 RECEPTOR ANTAGONIST - SPATIAL POSITIONING OF THESECONDARY ACID GROUP, Bioorganic & medicinal chemistry letters, 4(17), 1994, pp. 2077-2082
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
17
Year of publication
1994
Pages
2077 - 2082
Database
ISI
SICI code
0960-894X(1994)4:17<2077:SAOLAH>2.0.ZU;2-Z
Abstract
We report the preparation and pharmacologic activity of three spatial analogues of LY292728, a highly potent xanthone dicarboxylic LTB(4) re ceptor antagonist. Molecular modeling of these compounds has helped to further elucidate the nature of the secondary acid binding site of th e LTB(4) receptor.