VASOACTIVE EICOSANOIDS - SYNTHESIS OF 0-DIHYDROXYEICOSA-5(Z),8(Z),10(E),14(Z)-TETRAENOIC ACID VIA A NOVEL CHIRAL BIS-LACTOL

Authors
FALCK JR CHAUHAN K ROSOLOWSKY M CAMPBELL WB
Citation
Jr. Falck et al., VASOACTIVE EICOSANOIDS - SYNTHESIS OF 0-DIHYDROXYEICOSA-5(Z),8(Z),10(E),14(Z)-TETRAENOIC ACID VIA A NOVEL CHIRAL BIS-LACTOL, Bioorganic & medicinal chemistry letters, 4(17), 1994, pp. 2113-2116
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
17
Year of publication
1994
Pages
2113 - 2116
Database
ISI
SICI code
0960-894X(1994)4:17<2113:VE-SO0>2.0.ZU;2-8
Abstract
The type IIB eicosanoids, 12(R),20- and 12(S),20-dihydroxyeicosatetrae noic acid (DiHETE), were conveniently synthesized utilizing a carbohyd rate-derived bis-lactol as a differentiated 4-hydroxyhex-2(E)-enedial chiron. 12(S),20-DiHETE, but not the 12(R)-isomer, induced vasodilatio n in precontracted canine arteries.