SEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINS

Citation
Ils. Tersariol et al., SEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINS, Brazilian journal of medical and biological research, 27(9), 1994, pp. 2097-2102
Citations number
7
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
0100879X
Volume
27
Issue
9
Year of publication
1994
Pages
2097 - 2102
Database
ISI
SICI code
0100-879X(1994)27:9<2097:SOHP-I>2.0.ZU;2-S
Abstract
The sequence of the disaccharide units of eight heparan sulfate proteo glycans of different origins is described. All heparan sulfates contai n 5 variable regions made of oligosaccharide blocks of disaccharides, namely, GlcUA(1-4)GlcNAc, GlcUA(1-4)GlcNS, IdoUA (1-4) GlcNS,6S, IdoUA -GlcNAc,6S, and IdoUA,2S(1-4)GlcNS,6S, besides two constant regions ma de of an internal tetrasaccharide (IdoUA-GlcNAc-IdoUA-GlcNS) and monos accharides (GlcNS, and GlcNS,6S) at the non-reducing terminal. The N-a cetylated region of the heparan sulfates is linked to the serine of th e protein core through a trisaccharide of Xyl-Gal-Gal. Heparan sulfate s differ from one another in terms of the number of disaccharides that compose each block.