ADHESION TO LAMININ IS DOWN-REGULATED UPON RETINOIC ACID-INDUCED F9 CELL-DIFFERENTIATION - A ROLE FOR ALPHA6 BETA1 INTEGRIN/

Authors
ELIAS MCQB CHAMMAS R GIORGI RR FROCHTENGARTEN F SANTOS CLS BRENTANI RR
Citation
Mcqb. Elias et al., ADHESION TO LAMININ IS DOWN-REGULATED UPON RETINOIC ACID-INDUCED F9 CELL-DIFFERENTIATION - A ROLE FOR ALPHA6 BETA1 INTEGRIN/, Brazilian journal of medical and biological research, 27(9), 1994, pp. 2181-2184
Citations number
15
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Brazilian journal of medical and biological research → ACNP
ISSN journal
0100879X
Volume
27
Issue
9
Year of publication
1994
Pages
2181 - 2184
Database
ISI
SICI code
0100-879X(1994)27:9<2181:ATLIDU>2.0.ZU;2-6
Abstract
F9 mouse teratocarcinoma cells have a high capacity to adhere to lamin in and we identified alpha6/beta1 integrin as the principal laminin-bi nding protein present in these cells. F9 cells differentiated into par ietal endoderm when monolayer cultures were treated with retinoic acid and dibutyryl cyclic AMP. In this process a decreased adherence to la minin was observed due to a lower expression of alpha6/beta1 integrin on the cell surface.