1 1-MOLECULAR-COMPLEX OF TRIMETHOPRIM AND SULFAMETROLE/

In the complex between trimethoprim, 5-[(3,4,5-trimethoxyphenyl) methy l]-2,4-pyrimidinediamine, TMP, and sulfametrole, -methoxy-1,2,5-thiadi azol-3-yl)benzenesulfonamide, SMTR, C14H19N4O(3)(+).C9H9N4O3S(2)(-), t he proton participating in the hydrogen bond between the pyrimidine an d sulfonamide N atoms [2.808 (3)Angstrom] is transferred from SMTR to TMP (NH+...N-). An N-H...O hydrogen bond [2.933 (4)Angstrom] is also e stablished between the 2-aminopyrimidine group of TMP and an O atom of the sulfonamido group of SMTR. The bimolecular complex units are link ed in the crystal through N-H...O hydrogen bonds [3.057 (3)Angstrom] b etween p-aminophenyl and sulfonamido groups.