CLINICAL-EXPERIENCE WITH NIKKISO CENTRIFUGAL PUMPS FOR EXTRACORPOREAL-CIRCULATION

A comparative study of a newly developed impeller-type centrifugal pum p, Nikkiso HMS-15, was made to assess the effects on hemolysis, platel et function, and renal function for extracorporeal circulation (ECC) d uring open heart surgery. The Bio-pump (cone-type, Medtronic) and the roller pump were used as controls. The increase of serum hemoglobin le vel in the Nikkiso pump was significantly lower than that in the other pumps. The decrease of platelet counts was recognized after the initi ation of ECC in the three pumps whereas the levels of platelet factor 4 and beta-thromboglobulin in the Nikkiso pump group increased by far less than in the other two groups. Moreover, renal function was better maintained in the Nikkiso pump group; in particular, a significantly higher urine output was recorded during ECC and for 1 h after the term ination of ECC. The results of our clinical studies suggest that the N ikkiso centrifugal pump is suitable for ECC during open heart surgery.