THIORIDAZINE ENANTIOMERS IN HUMAN TISSUES

Enantiomers of thioridazine (TRZ) were determined in postmortem tissue s obtained from a patient on chronic TRZ therapy by sequential achiral and chiral high pressure liquid chromatography. Tissue concentrations of (+)-TRZ found in liver, brain, bile and blood were: 6.46, 0.40, 0. 48 and 0.07 mg/l or mg/kg, respectively. Concentrations of (-)-TRZ in liver, brain, bile and blood were: 12.2, 0.81, 1.07 and 0.20 mg/l or m g/kg, respectively. These data demonstrate the stereoselective disposi tion of TRZ in human tissues.