In order to evaluate the effect of immobilization during bed rest on m
ental health, we performed psychosomatic investigations of 6 young mal
es and 3 young females before, during and after 20 days bed rest. The
psychological state was repeatedly assessed by measuring the following
indices: 1) Zung's self-rating depression scale, 2) Cornell medical i
ndex, and 3) the General Health Questionnaire. Zung's self-rating depr
ession scale is a measure of the state of depression, while Cornell me
dical index and the General Health Questionnaire are utilized for dete
ction of neurosis. Although no influence of bedrest on Cornell medical
index was seen, Zung's self-rating depression scale and the General H
ealth Questionnaire displayed a tendency to development of depression
and neuroses, respectively. This tendency had disappeared 2 months aft
er the bed rest study. Both Zung's self-rating depression scale and th
e General Health Questionnaire may be appropriate indices to evaluate
the effects of relatively short-term psychological stress due to bed r
est. The urinary excretion of 17-hydroxycorticosteroid was used as an
indicator of endocrine stress factors, but no significant variation du
e to bed rest was seen. We concluded that there is a need for further
studies combining physiological research with psychosomatic investigat
ions.