ENZYMATIC RECOGNITION OF ACYCLIC UNIVERSAL BASE ANALOGS IN OLIGONUCLEOTIDES

Authors
LOAKES D VANAERSCHOT A BROWN DM HILL F
Citation
D. Loakes et al., ENZYMATIC RECOGNITION OF ACYCLIC UNIVERSAL BASE ANALOGS IN OLIGONUCLEOTIDES, Nucleosides & nucleotides, 15(11-12), 1996, pp. 1891-1904
Citations number
19
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
15
Issue
11-12
Year of publication
1996
Pages
1891 - 1904
Database
ISI
SICI code
0732-8311(1996)15:11-12<1891:EROAUB>2.0.ZU;2-0
Abstract
The effects of the acyclic analogues 3 and 4 on recognition by commonl y used enzymes in recombinant DNA work have been investigated. This re port shows that acyclic sugars can function in place of the normal 2'- deoxyribose moiety with some enzymes, expanding the range of possible manipulations.