CARBOCYCLIC SUBSTRATES AND INHIBITORS FOR THE BIFUNCTIONAL LYASE OF PURINE NUCLEOTIDE BIOSYNTHESIS

Authors
SCHMITT L CAPERELLI CA
Citation
L. Schmitt et Ca. Caperelli, CARBOCYCLIC SUBSTRATES AND INHIBITORS FOR THE BIFUNCTIONAL LYASE OF PURINE NUCLEOTIDE BIOSYNTHESIS, Nucleosides & nucleotides, 15(11-12), 1996, pp. 1905-1926
Citations number
29
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
15
Issue
11-12
Year of publication
1996
Pages
1905 - 1926
Database
ISI
SICI code
0732-8311(1996)15:11-12<1905:CSAIFT>2.0.ZU;2-9
Abstract
The carbocyclic analogs of succinoaminoimidazole carboxamide ribonucle otide (SAICAR) and adenylosuccinate (SAMP) are substrates for the bifu nctional lyase of purine biosynthesis, which catalyzes the elimination of fumarate from both SAICAR and SAMP to generate aminoimidazole carb oxamide ribonucleotide (AICAR) and AMP, respectively. The glutamate an alogs of both ribo- and carbo-SAICAR are inhibitors.