AZITHROMYCIN DOES NOT ALTER THE EFFECTS OF ORAL MIDAZOLAM ON HUMAN-PERFORMANCE

Since macrolide antibiotics inhibit the oxidative hepatic metabolism o f various drugs, including midazolam, the present double blind studies were conducted to find out if azithromycin, a new macrolide of the az alide type, would inhibit the metabolism of midazolam and enhance the effects of midazolam on human performance. In Study I, 64 healthy medi cal students, divided in four parallel groups received placebo, midazo lam (10 mg or 15 mg), and midazolam 10 mg combined with azithromycin ( 500 mg + 250 mg). In Study II, three males received oral midazolam 10 mg in combination with placebo, azithromycin or erythromycin 750 mg (a s a positive control) in a cross-over trial. Objective and subjective tests were done before the intake of midazolam and 30 and 90 min after it, and venous blood was sampled for the assay of midazolam. In the p lacebo group in Study I, the mean numbers of letters cancelled (LC) at baseline, 30 min and 90 min were 21, 20 and 20, respectively, and the corresponding mean numbers of correct digit symbol substitutions (DSS ) were 126, 137 and 140, indicating a practice effect. Midazolam 10 mg impaired these performances (21, 13 and 12 for LC, and 127, 113 and 1 11 for DSS). Either dose of midazolam produced clumsiness, mental slow ness and poor subjective performance, midazolam 15 mg being slightly m ore active. The corresponding, scores in the azithromycin + midazolam group were 21, 16, 16 for LC, and 132, 121 and 119 for DSS, the only s ignificant difference from placebo being the impairment of DSS at 90 m in. The combination differed from midazolam 15 mg in producing less dr owsiness and mental slowness. In Study II, mean plasma midazolam conce ntrations (mu g . l(-1) after erythromycin + midazolam 10 mg were 0 (b aseline), 168 (30 min) and 113 (90 min), which were higher than the va lues (0, 79 and 41) after placebo + midazolam. The corresponding conce ntrations (mu g . l(-1)) after azithromycin + midazolam (0, 85 and 46) were similar to those found after placebo + midazolam. Erythromycin b ut not azithromycin enhanced the objective and subjective effects of m idazolam. Our results suggest that as azithromycin, unlike erythromyci n, does not interfere with midazolam metabolism, it also does not enha nce the effects of midazolam.