Ce. Newlands et al., HYPERFERRITINEMIA ASSOCIATED WITH MALIGNANT HISTIOCYTOSIS IN A DOG, Journal of the American Veterinary Medical Association, 205(6), 1994, pp. 849-851
A 3.5-year-old male Golden Retriever with lethargy, generalized lympha
denopathy, and hepatosplenomegaly was determined to have malignant his
tiocytosis, based on the morphologic appearance of neoplastic cells by
light and electron microscopic examination, evidence of erythrophagoc
ytosis, the presence of diffuse nonspecific esterase activity, and imm
unohistochemical demonstration of vimentin intermediate filaments. Bec
ause of the appearance of abundant iron stores in the bone marrow, ser
um was obtained for determination of iron, total iron binding capacity
, and ferritin values. Serum ferritin concentrations were markedly inc
reased. Measurement of serum ferritin concentrations may be useful in
supporting a diagnosis of malignant histiocytosis, and the monitoring
of serum ferritin concentrations may be useful for assessing treatment
regression of the disease.