A diagnosis of degenerative joint disease secondary to an intra-articu
lar metallic foreign body in the right metacarpo-phalangeal joint was
made in a Quarter Horse gelding. Arthroscopy, performed to evaluate th
e joint and remove the foreign body, revealed yellow discoloration of
the articular cartilage and synovium, and blunting and proliferation o
f the synovium. The foreign body was identified as a lead sphere. Micr
oscopic examination of synovium revealed chronic synovitis, with accum
ulation of hemosiderin and multifocal, mild mineralization. Another pi
gment was evident extracellularly in the synovium. Lead arthropathy wa
s diagnosed. Lead arthropathy results from the dissolution of intra-ar
ticular lead, causing signs of chronic pain, restricted motion, joint
effusion, and synovial proliferation.