Psychosocial factors are implicated in the individual development, cou
rse and recovery from disease. Studies with animal models using social
interactions show that the magnitude and direction of changes in the
immune-, neuroendocrine-, and cardiovascular system are highly correla
ted with the social position of the animal. This relationship appears
to depend on the animalxs coping strategy both in terms of behaviour a
nd neuroendocrinology, and hence in immunology as well. It is argued t
hat disease processes should be considered as a function of the baseli
ne behavioural, neuroendocrine, and immunological state.