We report a mixed handed (L>R) patient with exclusive right cerebral l
anguage representation who developed a permanent anterograde amnestic
syndrome after right anterotemporal lobectomy. Preoperative neuropsych
ological performance consisted of impaired verbal memory and normal no
nverbal memory. Wada memory performance was asymmetrical for objects p
resented soon after amobarbital injection in conjunction with no memor
y asymmetry for items presented later in the Wada evaluation. Pre- and
postoperative magnetic resonance imaging (MRI) scans showed no struct
ural lesions; however, postoperative MRI hippocampal volume measuremen
ts suggested decreased hippocampal volume for the nonresected temporal
lobe. These results confirm the risk of anterograde amnesia after uni
lateral temporal lobectomy and demonstrate that baseline neuropsycholo
gical testing may falsely literalize material-specific memory function
s in patients with atypical cerebral language dominance.