Seventeen infants (7 boys and 10 girls) with visual abnormalities (suc
h as poor tracking and following and nystagmoid eye movement) and occi
pital slow activities with irregular polyspikes on EEG were studied. T
wo thirds of the children showed development of West syndrome with hyp
sarrhythmia on follow-up EEG. In 1 child, hypsarrhythmia was evident o
n the follow-up EEG, but no clinical seizures occurred. Because most o
f the children in our series developed West syndrome, patients with vi
sual abnormalities associated with occipital EEG discharges in early i
nfancy may be at high risk for West syndrome. Occipital abnormalities
in early infancy may relate to the occurrence of West syndrome.