OPTIMUM DOSE OF OLSALAZINE FOR MAINTAINING REMISSION IN ULCERATIVE-COLITIS

Citation
Spl. Travis et al., OPTIMUM DOSE OF OLSALAZINE FOR MAINTAINING REMISSION IN ULCERATIVE-COLITIS, Gut, 35(9), 1994, pp. 1282-1286
Citations number
22
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
GutACNP
ISSN journal
00175749
Volume
35
Issue
9
Year of publication
1994
Pages
1282 - 1286
Database
ISI
SICI code
0017-5749(1994)35:9<1282:ODOOFM>2.0.ZU;2-7
Abstract
To evaluate the optimum dose of olsalazine for maintaining remission i n ulcerative colitis, 198 patients in remission for more than three mo nths were randomly assigned to receive 0.5 g, 1.0 g, or 2.0 g/day for 12 months. A dose-ranging effect was detected in the per protocol anal ysis, with remission rates of 60% (0.5 g), 70% (1.0 g), and 78% (2.0 g ) (p=0.03, trend in proportions). The higher dose was most effective i n patients with proctitis (90% remission on 2 g/day, p=0.03) or those in remission for less than 12 months before the trial (88% remission o n 2 g/day, p=0.0006). There was little dose-ranging effect in patients with extensive colitis or those in remission for more than 12 months. Diarrhoea necessitated treatment withdrawal in 12%. The optimal dose of olsalazine for maintaining remission in ulcerative colitis is 1 g/d ay. For patients with proctitis or recent relapse, 2 g/day may be pref erable, although the dose seems to be less important in patients with more extensive disease or those in long term remission.