OXIDATION OF NUCLEIC-ACID RELATED-COMPOUNDS BY THE PEROXODISULFATE ION

Authors
ITAHARA T YOSHITAKE T KOGA S NISHINO A
Citation
T. Itahara et al., OXIDATION OF NUCLEIC-ACID RELATED-COMPOUNDS BY THE PEROXODISULFATE ION, Bulletin of the Chemical Society of Japan, 67(8), 1994, pp. 2257-2264
Citations number
64
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
67
Issue
8
Year of publication
1994
Pages
2257 - 2264
Database
ISI
SICI code
0009-2673(1994)67:8<2257:OONRBT>2.0.ZU;2-3
Abstract
The treatment of nucleic acid bases, nucleosides, and nucleotides with peroxodisulfate ion in a phosphate buffer solution at pH 7.0 or water at 70-75-degrees-C was investigated. The reaction of thymine and 5-me thylcytosine nucleosides and nucleotides resulted in the oxidation of the 5-methyl groups. The oxidation products from 1,3-dimethyluracils a nd the time-course of the reaction of uracils led to two plausible rea ction mechanisms for the oxidation of uracils.