Ni. Kunitsa et al., EFFECTS OF TOCOPHEROL AND ITS ANALOGS ON IN-VIVO LIPID-PEROXIDATION AND ELECTRON-TRANSPORT IN RAT-LIVER MITOCHONDRIA, Biochemistry, 58(11), 1993, pp. 1256-1259
In vivo effects of vitamin E and its analogs (alpha-tocopheryl acetate
with side chain shortened to six carbon atoms with either saturated o
r unsaturated bonds at the terminus, alpha-tocopherol, and alpha-tocop
heryl quinone without the side chain) on the rate of malonic dialdehyd
e formation, diene conjugate and total lipid contents in the liver, ac
tivity of respiratory chain enzymes (succinate and NADH dehydrogenase
and succinate and NADH-ubiquinone reductase), and vitamin E and ubiqui
none contents in liver mitochondria of vitamin E-deficient rats were i
nvestigated Alpha-tocopheryl acetate with side chain shortened to C6 a
nd with saturated bond at the chain terminus was found to be the most
effective analog of tocopherol. Further shortening of the tocopherol s
ide chain or conversion of tocopherol into quinone decreases the its a
ctivity.