The sick building syndrome has been widely discussed from epidemiologi
cal perspectives. Although there is considerable difference in opinion
regarding the concrete and objective evidence to support a distinct s
ick building syndrome and/or building-related illness, much data indic
ates that numerous variables within buildings can potentially influenc
e human health. In this paper, we discuss in detail not only the poten
tial and unique infectious diseases caused by Legionella, Pontiac feve
r, Q fever, and influenza, but also the data implicating noninfectious
etiologies of sick building syndrome and building-related illnesses.
In addition, the role of psychological factors, mass hysteria, and ind
oor pollution is discussed with respect to the nature of associations
between exposure and symptoms. Finally, comparisons are made in differ
ent building construction types of old versus new buildings to highlig
ht changes in modern construction that may have led to a putative incr
ease in work-related symptomatology.